Genome?wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy

LIM-domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome-wide level, which are crucial further understand their functions in cardiac hypertrophy, currently lacking. Here, 70 genes were identified characterised mice. The expression patterns differ greatly during case hypertrophy. Both Crip2 Xirp2 differentially expressed hypertrophy failure. In addition, hypertrophic state cardiomyocytes is controlled by relative levels Xirp2. This study provides a foundation for understanding special roles mammalian